Govind Shukla, Specializes in Pharmacology, Toxicology, Nutraceuticals & Herbal Drugs has published More than 100 research papers in National & International Journals. He is also a reviewer of International Journal of Pharmacology & pharmacotherapeutics, Chief editor of IJPNR Journal & Freelance Medical Writer for Different publication Groups including Lambert Academic Publishing Saarbrucken, Germany.


Nutraceuticals are dietary compounds which have a role in the balance of anabolic and catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism nutraceuticals is increasingly considered for the management and, above all, the prevention of osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium inflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial disease and, due to the great percentage of people suffering from it and the general increase in life expectancy, OA is considered as one of the most significant causes of disability in the world. OA impairs the structural integrity of articular cartilage that greatly depends on a balance between the anabolic and catabolic processes which occur in chondrocytes and synovial fluid of the joints, therefore the integration with nutraceutical compounds in diet increases the treatment options for patients with established OA beyond traditional rehabilitation, medications, and surgical strategies. FLEXAGOLD Tablets, A Synergistic blend of natural ingredients helps in supporting joint health. flexagold tablets  offers  a wide range of effects. They open new and large horizons for the treatment of degenerative joint diseases.

Pharmacological Action of each ingredients of flexagold tablets.

Boswellia Serrata Extract

The resin of Boswellia species has been used  in medicines since time immemorial. Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), grows in dry mountainous regions of India, Northern Africa and Middle East. Oleo gum-resin is tapped from the incision made on the trunk of the tree and is then stored in specially made bamboo basket for removal of oil content and getting the resin solidified. After processing, the gum-resin is then graded according to its flavour, colour, shape and size. The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes. Out of these four boswellic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation.

Glucosamine hydrochloride

Glucosamine is a naturally occurring substance found in the synovial fluid around our joints. It is naturally present in animal bones, bone marrow, shellfish and fungi . Glucosamine plays a vital role in building cartilage and is commonly consumed as a supplement by people with arthritis, especially osteoarthritis. Glucosamine is vital for building cartilage because it is a precursor for glycosaminoglycans which is a major component of joint cartilage. With aging, glucosamine levels go down, which can lead to eventual joint deterioration.

Several scientific studies have shown that glucosamine supplements may help patients with osteoarthritis (OA), especially of the hip or knee.

The effects of glucosamine are manifested by:

  • Reduction in osteoarthritis-related pain
  • Improved function in patients with knee or hip osteoarthritis
  • Reduced stiffness and swelling in the joints
  • Continued to provide relief of symptoms up to 3 months after patients stopped treatment.


Curcuminoids in Curcumin has been  demonstrated as antiapoptotic activity in Chondrocytes . Curcumin have been reported as ben¬eficial effect on cartilage matrix. This study was performed using immortalized human OA chondrocytes, which can explain the discordance with previous studies. However, one study tested the clinical efficacy of a herbomineral formulation containing a component rich in curcumin in people with OA in a rand¬omized, double-blind, placebo-controlled, crosso¬ver study. Positive results in pain management and mobility were obtained in the treated group. 

Bromelain extract

Bromelain is a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors. In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects. Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics. It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.

The studies investigating bromelain were a series of case reports on 28 patients, with moderate or severe rheumatoid or osteoarthritis.bromelain, was compared to diclofenac in 103 patients with osteoarthritis of the knee. After six weeks, both treatments resulted in significant and similar reduction in the pain and inflammation . Bromelain is a food supplement that may provide an alternative treatment to nonsteroidal anti-inflammatory drug (NSAIDs) . It plays an important role in the pathogenesis of arthritis. Bromelain has analgesic properties which are thought to be the result of its direct influence on pain mediators such as bradykinin.

Rose hip extract

Several human studies with Rose hip powder were carried out over the last couple of years . The powder showed pain reducing properties and could also reduce symptoms such as e.g. stiffness, or even the need for additional medication. However, the daily amount of approx. 5 g over a period of 12 weeks showed moderate beneficial effects, but also a low compliance  and demonstrated the limits of a treatment with Rose hip powder. Herbal drug powders are usually not as stable and uniform as extracts.

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